eVox® for Cognitive Measurement and Management

The eVox system is a state-of-the-art hardware and software system that allows for an objective and expansive functional measurement of brain and cognition. eVox facilitates early and continuous understanding of changes in cognitive function. As a result, it provides quantitative information for informed medical, nutritional, and behavioral biofeedback interventions to optimize patient outcomes.

eVox® for Cognitive Assessment and Management

The eVox system includes:

  • Workstation with a 24-channel amplifier
  • Assessment and treatment software
  • Two reusable EEG/ECG caps
  • Package of cloud-based eVox reports (one report per patient)
  • Assessment and treatment supplies
  • Secure physician’s web portal access

“Our practice focuses on the health care issues associated with aging. Memory loss is an issue that affects many of our patients. The eVox system helps us to quickly and objectively understand how the brain is functioning and provides important information we need to manage memory issues.”

– John McGee, MD (Board Certified Internal Medicine)

An Easy-to-use, Objective Tool to Help Identify and Assess Cognitive Impairment

Traditionally, cognitive impairment has been assessed through subjective tests such as the Mini-Mental Status Examination (MMSE). Now, with the eVox system, there is an objective tool to help identify and assess cognitive impairment.

The eVox system provides an objective and expansive functional measurement of the brain and cognition, using multiple electrophysiological technologies combined in one portable, non-invasive, easy-to-use, in-office device. These technologies include:

  • Electroencephalography (EEG)
  • Electrocardiography (ECG)
  • Event-Related Potential (ERP)

eVox has made these advanced tools available and easy to use in everyday clinical practice. The core electrophysiological modalities inside the eVox system are designed for identification and assessment of the dynamic changes that take place throughout the brain during cognitive processing tasks. This helps clinicians to:

  • Cognitive function
  • Cognitive impairment
  • Biomarkers associated with memory loss and cognitive impairment
  • Autonomic nervous system function
  • Physiologic function associated with:
    – Memory loss
    – Sleep disorders
    – Anxiety
    – Attention deficit
  • Level of cognitive impairment
  • Physiologic change in cognitive function over time
  • Change in cognitive performance (function) associated with clinical therapies
  • Impact on autonomic nervous system

Objectively Manage Memory Loss and Cognitive Function Over Time

eVox provides clinicians with objective data that has a high degree of sensitivity in detecting subtle variations in brain activity and performance. This makes the eVox system useful as an adjunct to traditional subjective clinical assessments when managing patients over time. Without the eVox system, subtle variations from the norm and longitudinal changes may otherwise go undetected.

Objectively Manage Memory Loss and Cognitive Function Over Time

The eVox system may be particularly effective in understanding a patient’s response to therapy during the earlier stages of pathology. This is a time when early identification of physiologic changes and proper clinical intervention may delay the progression of disease. The eVox system can provide valuable information for clinicians as they seek to objectively define their patients’ response to:

  • Pharmacologic therapy
  • Nutritional supplementation
  • Behavioral therapy
  • Diet and exercise
  • Neurotherapy

The eVox System Report

The eVox system generates a clear and actionable report of cognitive function that can be easily read and utilized by primary care physicians, mid-level practitioners, and behavioral specialists. This report includes visual and statistical data including:

  • Biomarkers
  • Visual processing
  • Auditory processing
  • Memory – via algorithm
  • Brain function map

The eVox system report includes actionable, objective data with clinical relevance across a range of cognitive functions. Physicians receive a one-page Summary Report that is intuitive, engaging, and easily shared with patients. Also included is a detailed, full length report including a two-page Memory Report and a second opinion service performed by NeuroRead that offers physicians another view of the electrophysiology data when considering the interpretation and clinical applications.


The self-report covers six areas of function. Memory reflects your brain’s memory function. Executive & Attention report on general cognitive functioning. Word Fluency reports on language interpretation and generation. Affect represents mood and self-worth. Sensory and Motor report on your senses like smell, taste, coordination, and motor skills. A low score in any of these categories suggests that you may be experiencing related symptoms.


The Peak Frequency is a general measure of cognitive ability and reflects your brain’s capacity for processing information. Results from the EEG about brain activity are shown on Brain Maps. Regions of your brain that are not functioning optimally are highlighted. Theta:Beta calculates the ratio of two standard brain wave frequencies, known as theta and beta waves. The Theta:Beta ratio has been shown to be higher in children, adolescents, and adults with ADHD than in those without it.

Response Measures

Response Speed measures in milliseconds (ms) how quickly your brain is communicating with your muscles. Response Consistency shows how variable your response speed was during testing. Information about your ability to pay attention can be drawn from the number of Missed Responses and Wrong Responses.

Heart Metrics

Heart Rate reports the average number of heart beats per minute (bpm). Heart Rate Variability (HRV) is based on the changing intervals between each individual heart beat. One analyzed metric of HRV is SDNN, also called rhythmicity. Another HRV metric is HRV Total Power, which reflects your ability to tolerate physical or mental stress. Autonomic Nervous System Activation shows if your nervous system is stressed (sympathetic), sluggish (parasympathetic), or ideally balanced.

Brain Speed

When analyzing brain speed, we measure how quickly information flows through the brain (speed), and how efficiently this information is being processed (power). Attention reflects your brain’s ability to notice and pay attention to new information. Information Processing reflects how well your brain classifies new information as important or irrelevant. Visual and Auditory processing informs on the health of your brain cells.

Hover your mouse over each report section number for more details.

Ordering eVox Reports

Each time you run a cognitive assessment test on a patient, a “report credit” is used. The report credit enables the workstation to perform the test and automatically generates a summary and detailed cloud-based eVox report. The eVox system comes with a package of report credits for you to get started. You can purchase additional report credits on Evoke’s secure and HIPAA compliant web portal. Package discounts are available for volume purchases. Report credit prices are independent of clinic charges and reimbursements.

© Copyright 2017 — Evoke Neuroscience, Inc.

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inc-500ISO 13485 CertifiedThe eVox system is a biofeedback device not intended to act as a diagnostic tool. The assessment component of the device provides valuable information on patient physiology associated with underlying neuropsychiatric pathologies that physicians can use as a tool, along with medical expertise and the patients’ relevant medical history, to make better informed decisions regarding a patient’s health and to plan individualized biofeedback.

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